PAR 1 contribution in acute electrophysiological properties of oral anticoagulants in rabbit pulmonary vein sleeve preparations

Whether oral anticoagulants, vitamin K antagonists ( VKA s), and nonvitamin K oral anticoagulant ( NOAC s) frequently prescribed to atrial fibrillation ( AF ) patients, do themselves have a pro‐ or anti‐arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental & clinical pharmacology 2018-08, Vol.32 (4), p.378-391
Main Authors: Font, Jonaz, Simeon, Mathilda, Simard, Christophe, Allouche, Stéphane, Plane, Anne‐Flore, Ferchaud, Virginie, Brionne, Marie, Rouet, René, Nowoczyn, Marie, Manrique, Alain, Puddu, Paolo Emilio, Milliez, Paul, Alexandre, Joachim
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whether oral anticoagulants, vitamin K antagonists ( VKA s), and nonvitamin K oral anticoagulant ( NOAC s) frequently prescribed to atrial fibrillation ( AF ) patients, do themselves have a pro‐ or anti‐arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute rabbit model of superfused pulmonary veins ( PV s) sleeves preparations using standard microelectrode technique. Fluindione 10 μ m ( n  = 6) increased the AP (action potential) duration ( APD ), induced a significantly V max depression (from 95 ± 14 to 53 ± 5 V/s, P 
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12365