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Illustrating the interplay between the extracellular matrix and micro RNA s
The discovery of cell surface receptors that bind to extracellular matrix ( ECM ) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profound...
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Published in: | International journal of experimental pathology 2014-06, Vol.95 (3), p.158-180 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The discovery of cell surface receptors that bind to extracellular matrix (
ECM
) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extracellular environment. Cell behaviour is profoundly affected by the
ECM
, whose synthesis and turnover must be finely balanced in order to maintain normal function and prevent disease. In the last decade, micro
RNA
s (mi
RNA
s) have emerged as key regulators of
ECM
gene expression. As new technologies for the identification and validation of mi
RNA
targets continue to be developed, a growing body of data supporting the role of mi
RNA
s in regulating the
ECM
biology has arisen from a variety of cell and animal models along with clinical studies. However, more recent findings suggest an intriguing interplay between the
ECM
and mi
RNA
s: not only can mi
RNA
s control the composition of the
ECM
, but also the
ECM
can affect the expression of specific mi
RNA
s. Here we discuss how mi
RNA
s contribute to the synthesis, maintenance and remodelling of the
ECM
during development and disease. Furthermore, we bring to light evidence that points to a role for the
ECM
in regulating mi
RNA
expression and function. |
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ISSN: | 0959-9673 1365-2613 |
DOI: | 10.1111/iep.12079 |