The MYST erious MOZ , a histone acetyltransferase with a key role in haematopoiesis

The MO nocytic leukaemia Z ing finger ( MOZ ; MYST3 or KAT6A 1 ) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical f...

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Bibliographic Details
Published in:Immunology 2013-06, Vol.139 (2), p.161-165
Main Authors: Perez‐Campo, Flor M., Costa, Guilherme, Lie‐a‐Ling, Michael, Kouskoff, Valerie, Lacaud, Georges
Format: Article
Language:English
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Summary:The MO nocytic leukaemia Z ing finger ( MOZ ; MYST3 or KAT6A 1 ) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.12072