Multipronged CD 4 + T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus

Over the last decade, the known spectrum of CD 4 + T‐cell effector subsets has become much broader, and it has become clear that there are multiple dimensions by which subsets with a particular cytokine commitment can be further defined, including their stage of differentiation, their location, and,...

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Bibliographic Details
Published in:Immunological reviews 2013-09, Vol.255 (1), p.149-164
Main Authors: Strutt, Tara M., McKinstry, K. Kai, Marshall, Nikki B., Vong, Allen M., Dutton, Richard W., Swain, Susan L.
Format: Article
Language:English
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Summary:Over the last decade, the known spectrum of CD 4 + T‐cell effector subsets has become much broader, and it has become clear that there are multiple dimensions by which subsets with a particular cytokine commitment can be further defined, including their stage of differentiation, their location, and, most importantly, their ability to carry out discrete functions. Here, we focus on our studies that highlight the synergy among discrete subsets, especially those defined by helper and cytotoxic function, in mediating viral protection, and on distinctions between CD 4 + T‐cell effectors located in spleen, draining lymph node, and in tissue sites of infection. What emerges is a surprising multiplicity of CD 4 + T‐cell functions that indicate a large arsenal of mechanisms by which CD 4 + T cells act to combat viruses.
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12088