Mg 0.5 Ni 0.5 Fe 2 O 4 nanoparticles as heating agents for hyperthermia treatment

• Published in: Journal of the American Ceramic Society 2019-05, Vol.102 (5), p.2752-2760
• Main Author: Hassanzadeh‐Tabrizi, Sayed A.
• Format: Article
• Language: English
• ISSN: 0002-7820; 1551-2916
• DOI: 10.1111/jace.16160

In the present work, Mg 0.5 Ni 0.5 Fe 2 O 4 nanopowders were prepared by a sol‐gel combustion method. The magnetic properties, heat generation ability in an AC magnetic field and cytotoxicity of the mixed ferrite nanopowders were investigated. The results showed that the powders have crystalline spinel structure with a particle size in the range of 20‐90 nm. Maximum saturation magnetization (Ms) of 51 emu/g was obtained for the Mg 0.5 Ni 0.5 Fe 2 O 4 nanoparticles calcined at 900°C. The results showed that, the coercivity (Hc) of the Mg 0.5 Ni 0.5 Fe 2 O 4 initially increases up to 700°C and then decreases with increasing temperature, whereas the Ms of the samples continuously increases. The Mg 0.5 Ni 0.5 Fe 2 O 4 sample exhibited a temperature increase up to 45°C during 10 minutes in the exposure of magnetic field of 200 Oe. By increasing the viscosity of ferrofluid, the heat generation ability of nanoparticles reduced up to 9% at magnetic field of 200 Oe. Cell compatibility of the ferrite powders was studied by MTT assay using MG 63 cell line proliferation. MTT results showed that calcination temperature of the Mg 0.5 Ni 0.5 Fe 2 O 4 nanoparticles significantly affects the cell compatibility.