Systemic antioxidant and anti‐inflammatory effects of yellow passion fruit bagasse extract during prostate cancer progression

• Published in: Journal of food biochemistry 2022-03, Vol.46 (3), p.e13885-n/a
• Main Authors: Baseggio, Andressa Mara, Kido, Larissa Akemi, Viganó, Juliane, Carneiro, Mara Junqueira, Lamas, Celina de Almeida, Martínez, Julian, Sawaya, Alexandra Christine Helena Frankland, Cagnon, Valéria Helena Alves, Maróstica Júnior, Mário Roberto
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants; Catalase; Cellulose; Fruit; Humans; inflammation; Inflammation - drug therapy; liver; Male; Mice; NF-kappa B - genetics; Passiflora; Passiflora edulis sp. Bagasse; piceatannol; Plant Extracts - pharmacology; Prostate; prostate cancer; Prostatic Neoplasms - drug therapy; redox status; Superoxide Dismutase; Tumor Necrosis Factor-alpha - genetics
• ISSN: 0145-8884; 1745-4514
• DOI: 10.1111/jfbc.13885

We evaluated the impact of yellow passion fruit (Passiflora edulis sp.) bagasse extract (PFBE) administration in systemic oxidative and inflammatory parameters in vivo, considering prostate cancer progression in transgenic mice (TRAMP). Piceatannol, scirpusin‐B, dicaffeoylquinic acid, citric acid, and (+)‐catechin were identified in PFBE, and the extract showed high in vitro antioxidant capacity. Some alterations in systemic parameters were verified during prostate cancer progression, as the increase in ALT and MDA levels, and SOD and GPx activities in the plasma. In the liver, higher MDA, TNF‐α, and NF‐κB levels, and GR and GPx activities were verified. Compared to their respective controls, the short‐ and long‐term PFBE administration reduced MDA levels in the liver and plasma. The long‐term treatment increased the catalase activity in the plasma, while the short‐term treatment increased the hepatic SOD and catalase activities. Still, a reduction in hepatic TNF‐α and NF‐κB levels was verified after long‐term treatment. Practical applications Prostate cancer progression is associated with changes in systemic redox status and inflammation markers. Moreover, the intake of polyphenols with antioxidant properties, besides delaying prostate carcinogenesis, may improve the systemic antioxidant defenses and inflammatory response. In vitro studies pointed to a promising antioxidant and anti‐inflammatory potential of yellow passion fruit bagasse. However, in vivo studies are scarce. Our results provided information about in vivo impacts of PFBE oral consumption on antioxidant defense and inflammation, indicating its potential as an adjuvant during the initial steps of prostate cancer. Prostate cancer progression alters systemic oxidative and inflammatory parameters in the TRAMP model. Some phytochemicals were identified in passion fruit bagasse extract (PFBE), as piceatannol, scirpusin‐B, (+)‐catechin and dicaffeoylquinic acid, and citric acid. PFBE presented antioxidant properties in vitro and in vivo, as well as anti‐inflammatory effects, and can act as an adjuvant during the initial steps of prostate cancer progression.