Pharmacokinetics of levamisole after intramuscular and oral administrations to Caspian salmon (Salmo trutta caspius)

The pharmacokinetic parameters of levamisole were determined in the Caspian salmon after intramuscular (IM), oral by gavage, and oral by feed administrations. Eighty‐one healthy fish in three different groups received levamisole at the dose of 25 mg/fish by each route. Blood samples were collected a...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2020-05, Vol.43 (3), p.276-281
Main Authors: Tabari, Mohaddeseh A., Youssefi, Mohammad Reza, Hosseinifard, Seyed Mehdi, Moghaddamnia, Ali Akbar, Kazemi, Sohrab, Sadati, NadAli Yousefi, Jalali Mothahari, Azadeh, Giorgi, Mario
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Area Under Curve
bioavailability
Biological Availability
Caspian salmon
Half-Life
Injections, Intramuscular
levamisole
Levamisole - administration & dosage
Levamisole - pharmacokinetics
pharmacokinetics
Salmon - blood
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Summary:The pharmacokinetic parameters of levamisole were determined in the Caspian salmon after intramuscular (IM), oral by gavage, and oral by feed administrations. Eighty‐one healthy fish in three different groups received levamisole at the dose of 25 mg/fish by each route. Blood samples were collected at time points of 0, 0.5, 1, 2, 4, 6, 12, 14, and 24 hr after administrations. Plasma levamisole concentrations were measured by a validated high‐performance liquid chromatography (HPLC) assay and were analyzed using a noncompartmental approach. The mean terminal half‐life was 4.56, 3.95, and 2.91 hr for IM, gavage and feed routes, respectively. The peak plasma concentration for IM, gavage, and feed routes of levamisole were 35.53, 4.63, and 8.36 µg/ml, respectively, at the time of 0.25 for IM, and 1 hr for gavage and feed. The relative bioavailability for gavage and feed routes was 54.80 and 69.30. The similar bioavailability for gavage and feed might be indicative of similar efficacy for these routes of administrations. Further studies are warranted to evaluate the absolute oral bioavailability and the effective dose in Caspian salmon.
ISSN:0140-7783
1365-2885
DOI:10.1111/jvp.12856