Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia

The most common identifiable causes of acute liver failure in pediatric patients are infection, drug toxicity, metabolic disease, and autoimmune processes. In many cases, the etiology of acute liver failure cannot be determined. Acute leukemia is an extremely rare cause of acute liver failure, and l...

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Bibliographic Details
Published in:Pediatric transplantation 2014-03, Vol.18 (2), p.E57-E63
Main Authors: Reddi, D. M., Barbas, A. S., Castleberry, A. W., Rege, A. S., Vikraman, D. S., Brennan, T. V., Ravindra, K. V., Collins, B. H., Sudan, D. L., Lagoo, A. S., Martin, A. E.
Format: Article
Language:English
Subjects:
acute liver failure
Adolescent
Biopsy
Humans
Immunosuppressive Agents - therapeutic use
Leukemia, B-Cell - complications
Leukemia, B-Cell - therapy
Liver - pathology
Liver Failure, Acute - complications
Liver Failure, Acute - surgery
Liver Function Tests
liver transplant
Liver Transplantation
Male
malignancy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Tissue Donors
Treatment Outcome
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Summary:The most common identifiable causes of acute liver failure in pediatric patients are infection, drug toxicity, metabolic disease, and autoimmune processes. In many cases, the etiology of acute liver failure cannot be determined. Acute leukemia is an extremely rare cause of acute liver failure, and liver transplantation has traditionally been contraindicated in this setting. We report a case of acute liver failure in a previously healthy 15‐yr‐old male from pre‐B‐cell acute lymphoblastic leukemia. He underwent liver transplantation before the diagnosis was established, and has subsequently received chemotherapy for pre‐B‐cell acute lymphoblastic leukemia. He is currently alive 31 months post‐transplantation. The published literature describing acute lymphoblastic leukemia as a cause of acute liver failure is reviewed.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12221