Bovine major histocompatibility complex (BoLA) heterozygote advantage against the outcome of bovine leukemia virus infection

Bovine leukemia virus (BLV) causes enzootic bovine leucosis. Host genetic heterozygosity at the major histocompatibility complex can enhance the ability to combat infectious diseases. However, heterozygote advantage is loci specific and depends on disease type. Bovine leukocyte antigen (BoLA)‐DRB3 p...

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Bibliographic Details
Published in:HLA : immune response genetics 2021-08, Vol.98 (2), p.132-139
Main Authors: Lo, Chieh‐Wen, Takeshima, Shin‐nosuke, Wada, Satoshi, Matsumoto, Yasunobu, Aida, Yoko
Format: Article
Language:English
Subjects:
association study
BoLA‐DRB3
bovine leukemia virus
heterozygosity
lymphoma
proviral load
resistance
susceptibility
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Summary:Bovine leukemia virus (BLV) causes enzootic bovine leucosis. Host genetic heterozygosity at the major histocompatibility complex can enhance the ability to combat infectious diseases. However, heterozygote advantage is loci specific and depends on disease type. Bovine leukocyte antigen (BoLA)‐DRB3 polymorphisms are related with BLV‐infection outcome; however, whether BoLA‐DRB3 heterozygotes have an advantage against BLV‐induced lymphoma and proviral load (PVL) remains unclear. By analyzing 1567 BLV‐infected individuals, we found that BoLA‐DRB3 heterozygous status was significantly associated with lymphoma resistance irrespective of cattle breeds (p 
ISSN:2059-2302
2059-2310
DOI:10.1111/tan.14285