HLA alleles associated to susceptibility to gliptin‐associated bullous pemphigoid in Italian patients

Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we a...

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Bibliographic Details
Published in:HLA : immune response genetics 2024-08, Vol.104 (2), p.n/a
Main Authors: Andreani, Marco, Mariotti, Feliciana, Pira, Anna, Locatelli, Franco, Testa, Giuseppe, Battarra, Mariarosa, Caputi, Priscilla, Scarabello, Alessandra, Bellei, Barbara, Campli, Cristiana Di, Collina, Maria Chiara, Esposito, Ilaria, Giampetruzzi, Anna Rita, Didona, Biagio, Pitocco, Dario, Simone, Clara De, Zenzo, Giovanni Di
Format: Article
Language:English
Subjects:
bullous pemphigoid
gliptin
HLA‐DQB103:01
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Summary:Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin‐associated BP (GABP) patients. A significant association between HLA‐DQB1*03:01 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes: DRB1*11:01, DRB3*02:02, DQA1*05:05, DQB1*03:01 or DRB1*11:04, DRB3*02:02, DQA1*05:05 and DQB1*03:01. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
ISSN:2059-2302
2059-2310
DOI:10.1111/tan.15616