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EVALUATION OF BRONCHOMOTOR AND PULMONARY VASOMOTOR ACTIVITY BY MEANS OF THE PERFUSED LIVING ANIMAL UNDER NEGATIVE PRESSURE VENTILATION
1. A description is given of a method for blood perfusion of the entire living animal (dog) in whichâ ( a ) the heart ventricles are put out of action and the right auricle continues to beat and respond to vagal stimulation, its blood-supply being intact; ( b ) the systemic and pulmonary blood-flo...
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| Published in: | Experimental physiology 1942-02, Vol.31 (3), p.227-262 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | 262 |
| container_issue | 3 |
| container_start_page | 227 |
| container_title | Experimental physiology |
| container_volume | 31 |
| creator | de Burgh Daly, I. Elsden, S. R. Hebb, Catherine O. Von Ludány, G. Petrovskaia, Barbara |
| description | 1. A description is given of a method for blood perfusion of the entire living animal (dog) in whichâ
( a ) the heart ventricles are put out of action and the right auricle continues to beat and respond to vagal stimulation, its
blood-supply being intact;
( b ) the systemic and pulmonary blood-flows, the gaseous content of the blood and the ventilation of the lungs are under separate
control;
( c ) the respiratory control remains active during 3 hours' perfusion and the blood gases are maintained within normal limits;
( d ) vascular and bronchomotor responses to sensory nerve stimulations and drug injections are readily obtained;
( e ) the blood-flows and pH values of the blood are rather lower than the corresponding values given by other workers for normal
unanæsthetised dogs.
2. Stimulation of the caudal ends of the cervical vagosympathetic nerves causes changes of pulmonary arterial pressure which
cannot be wholly accounted for by concomitant Åsophageal contractions or by bronchomotor effects. The significance of these
results in relation to pulmonary vasomotor nerve activity is discussed.
3. The bronchoconstriction due to excitation of the caudal end of the cervical vagus is potentiated by eserine and suppressed
by atropine, and is also potentiated by ergotoxine in the non-atropinised preparation.
We wish to express our thanks to the Government Grants Committee of the Royal Society for defraying the expenses of the investigation
by a grant to one of us (I. de B. D.). |
| doi_str_mv | 10.1113/expphysiol.1942.sp000859 |
| format | article |
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( a ) the heart ventricles are put out of action and the right auricle continues to beat and respond to vagal stimulation, its
blood-supply being intact;
( b ) the systemic and pulmonary blood-flows, the gaseous content of the blood and the ventilation of the lungs are under separate
control;
( c ) the respiratory control remains active during 3 hours' perfusion and the blood gases are maintained within normal limits;
( d ) vascular and bronchomotor responses to sensory nerve stimulations and drug injections are readily obtained;
( e ) the blood-flows and pH values of the blood are rather lower than the corresponding values given by other workers for normal
unanæsthetised dogs.
2. Stimulation of the caudal ends of the cervical vagosympathetic nerves causes changes of pulmonary arterial pressure which
cannot be wholly accounted for by concomitant Åsophageal contractions or by bronchomotor effects. The significance of these
results in relation to pulmonary vasomotor nerve activity is discussed.
3. The bronchoconstriction due to excitation of the caudal end of the cervical vagus is potentiated by eserine and suppressed
by atropine, and is also potentiated by ergotoxine in the non-atropinised preparation.
We wish to express our thanks to the Government Grants Committee of the Royal Society for defraying the expenses of the investigation
by a grant to one of us (I. de B. D.).</description><identifier>ISSN: 0958-0670</identifier><identifier>ISSN: 0033-5541</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1942.sp000859</identifier><language>eng</language><publisher>The Physiological Society</publisher><ispartof>Experimental physiology, 1942-02, Vol.31 (3), p.227-262</ispartof><rights>1942 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4007-ea9bef54b9c4001675f92ed1f2a9eaaf968967064303ec6aadf60ba5782178a53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.1942.sp000859$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.1942.sp000859$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,11541,27901,27902,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1113%2Fexpphysiol.1942.sp000859$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc></links><search><creatorcontrib>de Burgh Daly, I.</creatorcontrib><creatorcontrib>Elsden, S. R.</creatorcontrib><creatorcontrib>Hebb, Catherine O.</creatorcontrib><creatorcontrib>Von Ludány, G.</creatorcontrib><creatorcontrib>Petrovskaia, Barbara</creatorcontrib><title>EVALUATION OF BRONCHOMOTOR AND PULMONARY VASOMOTOR ACTIVITY BY MEANS OF THE PERFUSED LIVING ANIMAL UNDER NEGATIVE PRESSURE VENTILATION</title><title>Experimental physiology</title><description>1. A description is given of a method for blood perfusion of the entire living animal (dog) in whichâ
( a ) the heart ventricles are put out of action and the right auricle continues to beat and respond to vagal stimulation, its
blood-supply being intact;
( b ) the systemic and pulmonary blood-flows, the gaseous content of the blood and the ventilation of the lungs are under separate
control;
( c ) the respiratory control remains active during 3 hours' perfusion and the blood gases are maintained within normal limits;
( d ) vascular and bronchomotor responses to sensory nerve stimulations and drug injections are readily obtained;
( e ) the blood-flows and pH values of the blood are rather lower than the corresponding values given by other workers for normal
unanæsthetised dogs.
2. Stimulation of the caudal ends of the cervical vagosympathetic nerves causes changes of pulmonary arterial pressure which
cannot be wholly accounted for by concomitant Åsophageal contractions or by bronchomotor effects. The significance of these
results in relation to pulmonary vasomotor nerve activity is discussed.
3. The bronchoconstriction due to excitation of the caudal end of the cervical vagus is potentiated by eserine and suppressed
by atropine, and is also potentiated by ergotoxine in the non-atropinised preparation.
We wish to express our thanks to the Government Grants Committee of the Royal Society for defraying the expenses of the investigation
by a grant to one of us (I. de B. D.).</description><issn>0958-0670</issn><issn>0033-5541</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1942</creationdate><recordtype>article</recordtype><recordid>eNqNkMtOg0AUhidGE2v1HWbljjrDcJsl0mkhgaHhFruaTOlgMTUlYFJ5AZ9bEBu3rk7O5fv_nB8AiNECY0ye1GfTHPquPh0XmBr6omsQQo5Jr8AMGxbVDMN8uQYzRE1HQ5aNbsFd170hhAlyjBn4YoUb5m4WxBzGK_icxNzz4yjO4gS6fAk3eRjF3E22sHDTy9zLgiLItvB5CyPm8nQkM5_BDUtWecqWMBz2fD0IBJEbwpwvWQI5Ww82xXCVsDTNEwYLxrMg_PG-BzeVPHbq4bfOQb5imedrYbwOPDfUSgMhW1OS7lRlGjs69tiyzYrqao8rXVIlZUUthw4_WgZBRJWWlPvKQjtp2o6ObUeaZA6cSbdsT13Xqko0bf0u215gJMY8xV-eYsxTXPIcUG9Cz_VR9f_mBNv444Bgouv2oPI4qRzq18O5bpWYqO5U1uqjFwQLIsbDb0Sshvk</recordid><startdate>19420216</startdate><enddate>19420216</enddate><creator>de Burgh Daly, I.</creator><creator>Elsden, S. R.</creator><creator>Hebb, Catherine O.</creator><creator>Von Ludány, G.</creator><creator>Petrovskaia, Barbara</creator><general>The Physiological Society</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19420216</creationdate><title>EVALUATION OF BRONCHOMOTOR AND PULMONARY VASOMOTOR ACTIVITY BY MEANS OF THE PERFUSED LIVING ANIMAL UNDER NEGATIVE PRESSURE VENTILATION</title><author>de Burgh Daly, I. ; Elsden, S. R. ; Hebb, Catherine O. ; Von Ludány, G. ; Petrovskaia, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4007-ea9bef54b9c4001675f92ed1f2a9eaaf968967064303ec6aadf60ba5782178a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1942</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Burgh Daly, I.</creatorcontrib><creatorcontrib>Elsden, S. R.</creatorcontrib><creatorcontrib>Hebb, Catherine O.</creatorcontrib><creatorcontrib>Von Ludány, G.</creatorcontrib><creatorcontrib>Petrovskaia, Barbara</creatorcontrib><collection>CrossRef</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>de Burgh Daly, I.</au><au>Elsden, S. R.</au><au>Hebb, Catherine O.</au><au>Von Ludány, G.</au><au>Petrovskaia, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EVALUATION OF BRONCHOMOTOR AND PULMONARY VASOMOTOR ACTIVITY BY MEANS OF THE PERFUSED LIVING ANIMAL UNDER NEGATIVE PRESSURE VENTILATION</atitle><jtitle>Experimental physiology</jtitle><date>1942-02-16</date><risdate>1942</risdate><volume>31</volume><issue>3</issue><spage>227</spage><epage>262</epage><pages>227-262</pages><issn>0958-0670</issn><issn>0033-5541</issn><eissn>1469-445X</eissn><abstract>1. A description is given of a method for blood perfusion of the entire living animal (dog) in whichâ
( a ) the heart ventricles are put out of action and the right auricle continues to beat and respond to vagal stimulation, its
blood-supply being intact;
( b ) the systemic and pulmonary blood-flows, the gaseous content of the blood and the ventilation of the lungs are under separate
control;
( c ) the respiratory control remains active during 3 hours' perfusion and the blood gases are maintained within normal limits;
( d ) vascular and bronchomotor responses to sensory nerve stimulations and drug injections are readily obtained;
( e ) the blood-flows and pH values of the blood are rather lower than the corresponding values given by other workers for normal
unanæsthetised dogs.
2. Stimulation of the caudal ends of the cervical vagosympathetic nerves causes changes of pulmonary arterial pressure which
cannot be wholly accounted for by concomitant Åsophageal contractions or by bronchomotor effects. The significance of these
results in relation to pulmonary vasomotor nerve activity is discussed.
3. The bronchoconstriction due to excitation of the caudal end of the cervical vagus is potentiated by eserine and suppressed
by atropine, and is also potentiated by ergotoxine in the non-atropinised preparation.
We wish to express our thanks to the Government Grants Committee of the Royal Society for defraying the expenses of the investigation
by a grant to one of us (I. de B. D.).</abstract><pub>The Physiological Society</pub><doi>10.1113/expphysiol.1942.sp000859</doi><tpages>36</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Online Library Open Access |
| title | EVALUATION OF BRONCHOMOTOR AND PULMONARY VASOMOTOR ACTIVITY BY MEANS OF THE PERFUSED LIVING ANIMAL UNDER NEGATIVE PRESSURE VENTILATION |
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