Role of hyaluronic acid and phospholipid in the lubrication of a cobalt-chromium head for total hip arthroplasty

• Published in: Biointerphases 2014-09, Vol.9 (3), p.031007
• Main Authors: Park, Jong-Bong, Duong, Cong-Truyen, Chang, Ho-Geun, Sharma, Ashish R, Thompson, Mark S, Park, Sungchan, Kwak, Byung-Chan, Kim, Tae-Young, Lee, Sang-Soo, Park, Seonghun
• Format: Article
• Language: English
• Subjects: 1,2-Dipalmitoylphosphatidylcholine - pharmacology; Arthroplasty, Replacement, Hip - methods; Chemical Phenomena; Chromium - chemistry; Cobalt - chemistry; Humans; Hyaluronic Acid - pharmacology; Lubricants - pharmacology; Lubrication; Microscopy, Atomic Force; Prostheses and Implants
• ISSN: 1934-8630; 1559-4106
• DOI: 10.1116/1.4886255

The tribological performance of total hip arthroplasty has an important influence on its success rate. This study examined the concentration-dependent role of hyaluronic acid (HA) and phospholipid (dipalmitoylphosphatidylcholine, DPPC) in the boundary lubricating ability of retrieved cobalt-chromium femoral heads. The microscale frictional coefficients (μ) were measured by atomic force microscopy using a rectangular silicon cantilever integrated with sharp silicon tips. In the case of HA lubricant, the frictional coefficients decreased significantly at concentrations of 2.0 (0.16 ± 0.03) and 3.5 mg/ml (0.11 ± 0.01) while increased at 5.0 mg/ml (0.15 ± 0.01), compared to that with phosphate buffer saline (0.25 ± 0.03). The concentration-dependent lubrication behavior of DPPC was most effective when DPPC was in the physiological concentration range, showing μ = 0.16 ± 0.01 in polypropylene glycol, and 0.05 ± 0.01, 0.02 ± 0.01, and 0.03 ± 0.01 at a DPPC concentration of 0.05, 0.2, and 3.0 mg/ml, respectively. Results obtained show significant differences between the DPPC concentration groups. Conclusively, the microscale frictional response of the retrieved CoCr femoral head has a significant dependence on the concentrations of HA and DPPC. Moreover, observed optimal concentration of HA and DPPC for effective lubrication is similar to that observed in normal human synovial fluid. Therefore, a retrieval of the synovia may be considered during total hip replacement surgeries in an effort for reduction of friction between head and liner of total hip replacement implants.