Cervical cancer detection by time-resolved spectra of blood components

Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cel...

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Bibliographic Details
Published in:Journal of biomedical optics 2014-05, Vol.19 (5), p.057011-057011
Main Authors: Kalaivani, Rudran, Masilamani, Vadivel, AlSalhi, Mohamad Saleh, Devanesan, Sandhanasamy, Ramamurthy, P, Palled, Siddanna R, Ganesh, K. M
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biomarkers
Biomarkers, Tumor - blood
Blood
Blood Chemical Analysis - methods
Cancer
Control equipment
Decay
Discriminant Analysis
Female
Fluorescence
Humans
Middle Aged
Optical Imaging - methods
Patients
Porphyrins - blood
Reproducibility of Results
Spectra
Spectrometry, Fluorescence - methods
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - diagnosis
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Summary:Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cellular components of blood obtained from cervical cancer patients and normal controls are given. The cancer indicative biomarker in this paper is porphyrin; it has a fluorescence decay time of 60% more in samples of cancer patients than those of normal controls. Based on such measurements, a randomized set comprising samples from cancer patients and controls (N=27 in total) could be classified with sensitivity (92%) and specificity (86%).
ISSN:1083-3668
1560-2281
DOI:10.1117/1.JBO.19.5.057011