Hyperemic responses of the optic nerve head blood flow to chromatic equiluminant flicker are reduced by ocular hypertension and early glaucoma

We evaluated in ocular hypertension (OHT) and early glaucoma (EOAG) patients the optic nerve head (ONH) blood flow response (RFonh) to chromatic equiluminant flicker. This stimulus generates neural activity dominated by the parvo-cellular system. Eleven EOAG, 20 OHT patients, and 8 age-matched contr...

Full description

Saved in:
Bibliographic Details
Published in:Optical engineering 2014-06, Vol.53 (6), p.061706-061706
Main Authors: Falsini, Benedetto, Riva, Charles E, Salgarello, Tommaso, Logean, Eric, Colotto, Alberto, Giudiceandrea, Andrea
Format: Article
Language:English
Subjects:
Blood flow
Doppler effect
Flicker
Glaucoma
Hypertension
Lasers
Nerves
Patients
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated in ocular hypertension (OHT) and early glaucoma (EOAG) patients the optic nerve head (ONH) blood flow response (RFonh) to chromatic equiluminant flicker. This stimulus generates neural activity dominated by the parvo-cellular system. Eleven EOAG, 20 OHT patients, and 8 age-matched control subjects were examined. The blood flow (Fonh) at the neuroretinal rim was continuously monitored by laser Doppler flowmetry before, during, and after a 60-s exposure to a 4 Hz, red-green equiluminant flicker stimulus (30 deg field). RFonh was expressed as percentage Fonh-change during the last 20 s of flicker relative to baseline Fonh. Responses were collected at a number of temporal sites. The highest RFonh value was used for subsequent analysis. As compared to controls, both OHT and EOAG patients showed a decrease (p
ISSN:0091-3286
1560-2303
DOI:10.1117/1.OE.53.6.061706