Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging

The aim of this study was to compare functional cerebral hemodynamic signals obtained simultaneously by near infrared spectroscopy (NIRS) and by functional magnetic resonance imaging (fMRI). The contribution of superficial layers (skin and skull) to the NIRS signal was also assessed. Both methods we...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2001-04, Vol.28 (4), p.521-527
Main Authors: Toronov, Vladislav, Webb, Andrew, Choi, Jee Hyun, Wolf, Martin, Michalos, Antoios, Gratton, Enrico, Hueber, Dennis
Format: Article
Language:English
Subjects:
biomedical MRI
brain
Brain - pathology
brain imaging
Clinical applications
fMRI
haemodynamics
Hemodynamics
Humans
infrared spectroscopy
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Models, Theoretical
near infrared
Near infrared imaging
Neuroscience
Physicists
Pneumodyamics, respiration
Signal generators
Skin
Skin - pathology
Skull - pathology
Spectroscopy
Spectroscopy, Near-Infrared - methods
Time Factors
Tissues
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Summary:The aim of this study was to compare functional cerebral hemodynamic signals obtained simultaneously by near infrared spectroscopy (NIRS) and by functional magnetic resonance imaging (fMRI). The contribution of superficial layers (skin and skull) to the NIRS signal was also assessed. Both methods were used to generate functional maps of the motor cortex area during a periodic sequence of stimulation by finger motion and rest. In all subjects we found a good collocation of the brain activity centers revealed by both methods. We also found a high temporal correlation between the BOLD signal (fMRI) and the deoxy-hemoglobin concentration (NIRS) in the subjects who exhibited low fluctuations in superficial head tissues.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.1354627