Practical aspects of functional MRI (NMR Task Group #8)

Functional MR imaging (fMRI) based upon the Blood Oxygen Level Dependent (BOLD) effect is currently an important new tool for understanding basic brain function and specifically allowing the correlation of physiological activity with anatomical location without the use of ionizing radiation. The cli...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2002-08, Vol.29 (8), p.1892-1912
Main Authors: Price, Ronald R., Allison, Jerry, Massoth, Richard J., Clarke, Geoffrey D., Drost, Dick J.
Format: Article
Language:English
Subjects:
biomedical MRI
blood
BOLD Effect
brain
Brain - anatomy & histology
Brain - physiopathology
Brain Diseases - diagnosis
Brain Diseases - physiopathology
Cerebrovascular Circulation
fMRI
functional Magnetic Resonance Imaging
Humans
Image analysis
Image Enhancement
Ionizing radiation
Magnetic resonance imaging
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
medical image processing
Medical imaging
Medical magnetic resonance imaging
Medical physicists
MRI functional imaging
Neuroscience
Nuclear magnetic resonance
Nuclear magnetic resonance imaging
Oxygen - blood
Physicists
Pulse sequences
Spin Labels
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Summary:Functional MR imaging (fMRI) based upon the Blood Oxygen Level Dependent (BOLD) effect is currently an important new tool for understanding basic brain function and specifically allowing the correlation of physiological activity with anatomical location without the use of ionizing radiation. The clinical role of fMRI is still being defined and is the subject of much research activity. In this report we present the underlying physical, technical and mathematical principals of BOLD fMRI along with descriptions of typical applications. Our purpose in this report is to provide, in addition to basic principles, an insight into the aspects of BOLD imaging, which may be used by the medical physicist to assist in the implement of fMRI procedures in either a hospital or research environment.
ISSN:0094-2405
2473-4209
DOI:10.1118/1.1494990