Nonlinear ultrasound fields generated by a 256-element spiral array for boiling histotripsy

Boiling histotripsy (BH) is a HIFU approach that uses millisecond-long ultrasound bursts with high-amplitude shocks to mechanically fractionate tissue. In this work, the performance of a BH pre-clinical system operating at 1.5 MHz was characterized by hydrophone measurements in water and lesion form...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2018-09, Vol.144 (3), p.1700-1700
Main Authors: Khokhlova, Tatiana D., Kreider, Wayne, Hunter, Christopher, Ghanem, Mohamed A., Cunitz, Bryan, Sapozhnikov, Oleg A., Khokhlova, Vera A.
Format: Article
Language:English
Online Access:Get full text
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Summary:Boiling histotripsy (BH) is a HIFU approach that uses millisecond-long ultrasound bursts with high-amplitude shocks to mechanically fractionate tissue. In this work, the performance of a BH pre-clinical system operating at 1.5 MHz was characterized by hydrophone measurements in water and lesion formation capabilities were tested in ex vivo tissue. The system comprises a 256 element array driven by Verasonics Ultrasound Engine with a 1.2 kW external power source enhanced by an additional capacitor bank. The maximum pulse average acoustic power of the system was 2.2 kW (as measured by radiation force balance), sustained for 10 ms with
ISSN:0001-4966
1520-8524
DOI:10.1121/1.5067552