Antibody Conjugates and Therapeutic Strategies

Immunotherapeutics represent the largest group of molecules currently in development as new drug entities. These versatile molecules are being investigated for the treatment of a range of pathological conditions including cancer, infectious and inflammatory diseases. Antibodies can be used to exert...

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Bibliographic Details
Published in:Molecular interventions 2005-12, Vol.5 (6), p.368-380
Main Authors: McCarron, Paul A, Olwill, Shane A, Marouf, Waleed M Y, Buick, Richard J, Walker, Brian, Scott, Christopher J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - chemistry
Antibodies, Monoclonal - therapeutic use
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Drug Carriers - chemistry
Drug Delivery Systems
Humans
Immunoconjugates - administration & dosage
Immunoconjugates - chemistry
Immunoconjugates - therapeutic use
Immunotherapy
Immunotoxins - administration & dosage
Immunotoxins - chemistry
Immunotoxins - therapeutic use
Mice
Nanostructures
Peptides - administration & dosage
Peptides - chemistry
Peptides - therapeutic use
Radioisotopes - therapeutic use
Recombinant Proteins - administration & dosage
Recombinant Proteins - chemistry
Recombinant Proteins - therapeutic use
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Summary:Immunotherapeutics represent the largest group of molecules currently in development as new drug entities. These versatile molecules are being investigated for the treatment of a range of pathological conditions including cancer, infectious and inflammatory diseases. Antibodies can be used to exert biological effects themselves or as delivery agents of conjugated drug molecules. Site-specific delivery of therapeutic agents has been an ultimate goal of the pharmaceutical industry in order to maximize drug action and minimize side effects. Antibodies have the potential to realize this objective and in this review we will examine some of the main strategies currently being employed for the development of these diverse therapeutic molecules.
ISSN:1534-0384
1543-2548
DOI:10.1124/mi.5.6.9