Adrenaline-Forming Enzyme in Brainstem: Elevation in Genetic and Experimental Hypertension

The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A$_{1}$ and A$_{2}$ regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A$_{1}$ region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hyperten...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-02, Vol.191 (4226), p.483-484
Main Authors: Saavedra, Juan M., Grobecker, Horst, Axelrod, Julius
Format: Article
Language:English
Subjects:
Alcohols
Blood pressure
Blood Pressure - drug effects
Brain stem
Brain Stem - enzymology
Desoxycorticosterone - pharmacology
Enzymes
Ethanol
Hypertension
Hypertension - chemically induced
Hypertension - enzymology
Hypertension - genetics
Hypertension - physiopathology
Locus coeruleus
Nerves
Neurons
Phenylethanolamine N-Methyltransferase - antagonists & inhibitors
Phenylethanolamine N-Methyltransferase - metabolism
Pyridines - pharmacology
Seizures
Thiophenes - pharmacology
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Summary:The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A$_{1}$ and A$_{2}$ regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A$_{1}$ region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1246633