Convulsant Drug Action on Neuronally Isolated Cerebral Cortex

After topical application of thiosemicarbazide, semicarbazide, or isoniazid to the surface of an isolated region of cortex, convulsive responses to electrical stimulation appeared only after a finite number of normal responses had been elicited, and disappeared again if stimulation was interrupted f...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1963-11, Vol.142 (3594), p.973-975
Main Author: Grafstein, Bernice
Format: Article
Language:English
Subjects:
Albumins
Aorta
Cats
Central Nervous System Stimulants
Cerebral Cortex
Convulsants
Electrodes
Hydrazides
Isoniazid
Lipoproteins
Pharmacologic actions
Pharmacology
Sound
Strychnine
Thiosemicarbazones
Thoracic aorta
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Summary:After topical application of thiosemicarbazide, semicarbazide, or isoniazid to the surface of an isolated region of cortex, convulsive responses to electrical stimulation appeared only after a finite number of normal responses had been elicited, and disappeared again if stimulation was interrupted for about 10 minutes. With any of the other convulsant drugs tested, development of the convulsive pattern was independent of whether or not the cortex was stimulated. The two groups of drugs evidently have different modes of action.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.142.3594.973