Radiation-Induced Mouse Leukemia: Consistent Occurrence of an Extra and a Marker Chromosome

Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1964-02, Vol.143 (3608), p.810-813
Main Authors: Wald, Niel, Upton, Arthur C., Jenkins, Vernon K., Borges, Wayne H.
Format: Article
Language:English
Subjects:
Animals
Blood
Bone marrow
Bone Marrow Cells
Cell nucleolus
Chromosome Aberrations
Chromosomes
Leukemia
Leukemia, Radiation-Induced
Lymphocytes
Mice
Myeloid leukemia
Spleen
Spleen cells
Viruses
X-Rays
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Summary:Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.143.3608.810