17β-Estradiol: Inducer of Uterine Hexokinase

Administration of estradiol to ovariectomized rats induced new synthesis of uterine hexokinase which was prevented by actinomycin D, 5-fluorouracil, cycloheximide, or ethionine. The estradiol-induced increase in uterine hexokinase activity was detectable as early as 4 hours. The increase in enzyme a...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-03, Vol.159 (3818), p.990-991
Main Authors: Valadares, J. R. E., Singhal, Radhey L., Parulekar, M. R.
Format: Article
Language:English
Subjects:
Actinomycin
Biosynthesis
Enzyme activity
Enzymes
Estrogens
Hormones
Protein synthesis
RNA
Statistical significance
Uterus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Administration of estradiol to ovariectomized rats induced new synthesis of uterine hexokinase which was prevented by actinomycin D, 5-fluorouracil, cycloheximide, or ethionine. The estradiol-induced increase in uterine hexokinase activity was detectable as early as 4 hours. The increase in enzyme activity was dependent upon the dose of the hormone. The evidence indicates that the increased hexokinase activity induced by 17β-estradiol may entail an acceleration of the synthesis of certain RNA species.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.159.3818.990