Graft versus Host Inhibition: Fetal Liver and Thymus Cells to Minimize Secondary Disease

Long-lived radiation chimeras were produced in mice differing at the major histocompatibility locus. Survival occurred in lethally irradiated recipients inoculated with allogeneic fetal liver and allogeneic fetal thymus cells in combination. The survival rate was equal or superior to that of mice wi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-04, Vol.164 (3877), p.316-318
Main Authors: Bortin, Mortimer M., Saltzstein, Edward C.
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Chimeras
Female
Fetal diseases
Fetus
Graft vs Host Disease - immunology
Histocompatibility
Immunity - radiation effects
Liver
Liver - cytology
Liver - embryology
Liver - immunology
Liver cells
Mice
Pregnancy
Radiation Injuries, Experimental - mortality
Spleen
Spleen cells
Survival rates
Thymus Gland - cytology
Thymus Gland - embryology
Thymus Gland - immunology
Tissue grafting
Transplantation, Homologous
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Description
Summary:Long-lived radiation chimeras were produced in mice differing at the major histocompatibility locus. Survival occurred in lethally irradiated recipients inoculated with allogeneic fetal liver and allogeneic fetal thymus cells in combination. The survival rate was equal or superior to that of mice with transplanted syngeneic fetal, neonatal, or adult hematopoietic cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.164.3877.316