Serum C′3 Lytic System in Patients with Glomerulonephritis

The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C′3 is 80 to 90 percent complete in 20 minutes at 37 °C and pH 7....

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-04, Vol.164 (3878), p.436-437
Main Authors: Spitzer, R. E., Vallota, E. H., Forristal, J., Sudora, E., Stitzel, A., Davis, N. C., West, C. D.
Format: Article
Language:English
Subjects:
Antigens
Glomerulonephritis
Nephritis
Reactants
Serum globulins
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Summary:The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C′3 is 80 to 90 percent complete in 20 minutes at 37 °C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.164.3878.436