Mouse Leukemia Virus Activation by Chemical Carcinogens

The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-12, Vol.166 (3913), p.1624-1626
Main Authors: Igel, Howard J., Huebner, Robert J., Turner, Horace C., Kotin, Paul, Falk, Hans L.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Antigens
Carcinogens
Complement Fixation Tests
Leukemia
Leukemia Virus, Murine - immunology
Lymphoma
Lymphoma - chemically induced
Lymphoma - immunology
Male animals
Methylcholanthrene
Mice
Molecules
Murine leukemia virus
Nitrosamines
Salts
Urethane
Viruses
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Description
Summary:The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.166.3913.1624