Bladder Cancer Induction by Aromatic Amines: Role of N-Hydroxy Metabolites

Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1970-02, Vol.167 (3920), p.992-993
Main Authors: Radomski, Jack L., Brill, Earl
Format: Article
Language:English
Subjects:
Amines
Amines - metabolism
Animals
Carcinogenicity
Carcinogens - metabolism
Children
Cystic fibrosis
Dogs
Dosage
Human genetics
Methemoglobinemia - chemically induced
Naphthalenes - metabolism
Oxidation-Reduction
Urinary bladder
Urinary Bladder Neoplasms - chemically induced
Urine
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Summary:Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.167.3920.992