Hycanthone: A Frameshift Mutagen

Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1971-06, Vol.172 (3987), p.1058-1060
Main Authors: Hartman, Philip E., Levine, Kathryn, Hartman, Zlata, Berger, Hillard
Format: Article
Language:English
Subjects:
Anthelmintics - pharmacology
Bacteria
Bacteriophages
Cell culture techniques
Coliphages - drug effects
Genetic mutation
Histidine - metabolism
Lucanthone - pharmacology
Medical genetics
Mutagenicity
Mutagens
Mutagens - pharmacology
Mutation
Nonsense
Salmonella
Salmonella - drug effects
Test systems
Xanthenes - pharmacology
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Description
Summary:Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.172.3987.1058