Noncytokinetic Radiation Injury: Anticoagulants as Radioprotective Agents in Experimental Radiation Hepatitis

Rats that have been irradiated with a single dose of 1500 roentgens directed to the liver show the following abnormalities: increased clearance of colloidal gold by the liver at 30 days, a decreased albumin space index at 30 days, and increased alkaline phosphatase at 60 days. In each of these cases...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-03, Vol.175 (4029), p.1481-1483
Main Authors: Kinzie, J., Studer, Rebecca K., Perez, Blanca, Potchen, E. James
Format: Article
Language:English
Subjects:
Albumins
Albumins - metabolism
Animals
Blood Coagulation Tests
Dams
Female
Gold Colloid, Radioactive
Heparin
Heparin - administration & dosage
Heparin - therapeutic use
Hepatitis - prevention & control
Iodine Isotopes
Irradiation
Liver
Liver - metabolism
Liver - pathology
Liver - radiation effects
Metabolic Clearance Rate
Pups
Radiation dosage
Radiation injuries
Radiation Injuries, Experimental - metabolism
Radiation Injuries, Experimental - pathology
Radiation Injuries, Experimental - prevention & control
Radiation-Protective Agents
Rats
Salicylates
Salicylates - administration & dosage
Salicylates - therapeutic use
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Summary:Rats that have been irradiated with a single dose of 1500 roentgens directed to the liver show the following abnormalities: increased clearance of colloidal gold by the liver at 30 days, a decreased albumin space index at 30 days, and increased alkaline phosphatase at 60 days. In each of these cases, animals receiving Depo-heparin in dose ranges reasonable for human application had essentially normal values. There was no radioprotective effect with salicylates at the doses used. Higher doses of salicylates resulted in death of the animals.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.175.4029.1481