Response Decrements in the Cochlear Nucleus of Decerebrate Cats during Repeated Acoustic Stimulation

In the cochlear nucleus of decerebrate, paralyzed cats, multiple-unit responses to an acoustic stimulus showed significant decrements when the stimulus was repeatedly presented once every 5 seconds. These decrements developed in the absence of peripheral receptor adaptation. The responses recovered...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-03, Vol.175 (4029), p.1488-1491
Main Authors: Humphrey, Gordon L., Buchwald, Jennifer S.
Format: Article
Language:English
Subjects:
Absorption spectra
Acoustic stimulation
Animals
Auditory Pathways - physiology
Brain Stem - physiology
Cats
Cochlear Nerve - physiology
Cochlear nucleus
Decerebrate State
Evoked Potentials
Habituation
Habituation, Psychophysiologic
Neurons
Noise
Physiology
Pigments
Receptors
Round window
Sound
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Summary:In the cochlear nucleus of decerebrate, paralyzed cats, multiple-unit responses to an acoustic stimulus showed significant decrements when the stimulus was repeatedly presented once every 5 seconds. These decrements developed in the absence of peripheral receptor adaptation. The responses recovered to the level prior to stimulation when stimulation was withheld for 5 to 10 minutes. Dishabituation by somatic stimulation of the forepaw, however, was less effective than in the intact cat. The continued development of response decrements after strychnine blockade of peripheral olivocochlear influences and central postsynaptic inhibition suggests a mechanism of decreased synaptic effectiveness, which has previously been postulated for neuronal habituation in brainstem and spinal cord.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.175.4029.1488