Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension

Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevente...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1972-09, Vol.177 (4054), p.1108-1109
Main Authors: Miller, Edward D., Samuels, Alan I., Haber, Edgar, Barger, A. Clifford
Format: Article
Language:English
Subjects:
Angiotensin II - metabolism
Animals
Blood plasma
Blood pressure
Blood Pressure - drug effects
Bradykinin - blood
Catheters
Dogs
Enzymes
Hypertension
Hypertension, Renal - metabolism
Injections, Intravenous
Intravenous injections
Male
Molecules
Peptides - administration & dosage
Peptides - isolation & purification
Peptides - pharmacology
Renal artery
Renin - blood
Renovascular hypertension
RNA
Venoms - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normal in the early phase of renovascular hypertension. These results offer strong evidence that the renin-angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.177.4054.1108