Toxaphene Insecticide: A Complex Biodegradable Mixture

Adsorption and gas-liquid chromatography separate toxaphene into at least 175 polychlorinated 10-carbon compounds including Cl$_{6}$, Cl$_{7}$, Cl$_{8}$, Cl$_{9}$, and Cl$_{10}$ derivatives. One toxic component is 2,2,5-endo,6-exo,8,9,10-heptachlorobornane. Rats metabolically dechlorinate toxaphene,...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1974-02, Vol.183 (4124), p.520-521
Main Authors: Casida, John E., Holmstead, Roy L., Khalifa, Safy, Knox, John R., Ohsawa, Tomihiko, Palmer, Kenneth J., Wong, Rosalind Y.
Format: Article
Language:English
Subjects:
Acclimatization
Animals
Biodegradation
Carbon Radioisotopes
Chemical composition
Chlorides
Chlorine - metabolism
Chromatography
Chromatography, Gas
Feces - analysis
Insecticides
Insecticides - metabolism
Metabolism
Phosphates
Radioisotope Dilution Technique
Radioisotopes
Rats
Toxaphene - analysis
Toxaphene - isolation & purification
Toxaphene - metabolism
Toxaphene - toxicity
Toxaphene - urine
Toxicity
Urine
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Summary:Adsorption and gas-liquid chromatography separate toxaphene into at least 175 polychlorinated 10-carbon compounds including Cl$_{6}$, Cl$_{7}$, Cl$_{8}$, Cl$_{9}$, and Cl$_{10}$ derivatives. One toxic component is 2,2,5-endo,6-exo,8,9,10-heptachlorobornane. Rats metabolically dechlorinate toxaphene, removing about half of the chlorine from the technical insecticide and from each of seven subfractions of varying composition and toxicity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.183.4124.520