The CD14 Monocyte Differentiation Antigen Maps to a Region Encoding Growth Factors and Receptors

CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chrom...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-01, Vol.239 (4839), p.497-500
Main Authors: Goyert, Sanna M., Ferrero, Enza, Rettig, Wolfgang J., Yenamandra, Aswani K., Obata, Fumiya, Le Beau, Michelle M.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3. Analyses of complementary DNA and genomic clones of CD14 show that it has a novel structure and that it maps to chromosome 5 within a region containing other genes encoding growth factors and receptors; it may therefore represent a new receptor important for myeloid differentiation. In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2448876