Genetic Susceptibility to Leishmania: IL-12 Responsiveness in T$_H$1 Cell Development

The genetic background of T lymphocytes influences development of the T helper (T$_H$) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells t...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-02, Vol.271 (5251), p.984-987
Main Authors: Güler, Mehmet L., Gorham, James D., Hsieh, Chyi-Song, Mackey, Aaron J., Steen, Robert G., Dietrich, William F., Murphy, Kenneth M.
Format: Article
Language:English
Subjects:
Antibodies
Circles
Coculture techniques
Cultured cells
Cytokines
Infections
Phenotypes
Spleen cells
Splenocytes
T lymphocytes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The genetic background of T lymphocytes influences development of the T helper (T$_H$) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced T$_H$1 responses rather than from an IL-4-induced T$_H$2 response.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.271.5251.984