Tris(2-3 dibromopropyl) phosphate: mutagenicity of a widely used flame retardant

Tris(2,3-dibromopropyl) phosphate, a widely used flame-retardant additive for textiles, is mutagenic to histidine-requiring strains of Salmonella typhimurium. Extracts of fabrics treated with this compound are also capable of inducing mutations in these bacterial strains.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-01, Vol.195 (4273), p.76-78
Main Authors: Prival, M.J, McCoy, E.C, Gutter, B, Rosenkranz, H.S
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biological Assay
Clothing - adverse effects
consumer education
consumer protection
consumer science
Dose-Response Relationship, Drug
Flame retardants
human nutrition
Hydrocarbons, Brominated
Liver
Microsomes
Microsomes, Liver - metabolism
Mutagenicity
Mutagens
Organophosphorus Compounds - adverse effects
Organophosphorus Compounds - metabolism
Phosphates
Polyesters
Rats
Salmonella typhimurium
Salmonella typhimurium - drug effects
Skin - metabolism
Sulfoxides
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Description
Summary:Tris(2,3-dibromopropyl) phosphate, a widely used flame-retardant additive for textiles, is mutagenic to histidine-requiring strains of Salmonella typhimurium. Extracts of fabrics treated with this compound are also capable of inducing mutations in these bacterial strains.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.318761