Brain Edema: Induction in Cortical Slices by Polyunsaturated Fatty Acids

The presence of polyunsaturated and saturated fatty acids in leukocytic membranes prompted study of their possible role in the induction of brain edema. Polyunsaturated fatty acids including sodium arachidonate, sodium linoleate, sodium linolenate, and docosahexaenoic acids induced edema in slices o...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1978-07, Vol.201 (4353), p.358-360
Main Authors: Chan, Pak Hoo, Fishman, Robert A.
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acids
Brain edema
Brain Edema - chemically induced
Cerebral Cortex
Detergents
Dose-Response Relationship, Drug
Ethanol
Fatty acids
Fatty Acids, Unsaturated
Granulocytes - physiology
Hydroxy Acids
In Vitro Techniques
Lactates
Lipids
Nonesterified fatty acids
Prostaglandins
Rats
Sodium
Sodium Dodecyl Sulfate
Standard error
Swelling
Unsaturated fatty acids
Water-Electrolyte Imbalance - chemically induced
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Summary:The presence of polyunsaturated and saturated fatty acids in leukocytic membranes prompted study of their possible role in the induction of brain edema. Polyunsaturated fatty acids including sodium arachidonate, sodium linoleate, sodium linolenate, and docosahexaenoic acids induced edema in slices of rat brain cortex. This cellular edema was specific, since neither saturated fatty acids nor a fatty acid containing a single double bond had such effect.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.663662