Radiosensitization of Hypoxic Tumor Cells by Depletion of Intracellular Glutathione

Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1982-08, Vol.217 (4559), p.544-545
Main Authors: Bump, Edward A., Yu, Ning Y., Brown, J. Martin
Format: Article
Language:English
Subjects:
Animals
Cell Survival - drug effects
Cell Survival - radiation effects
Cells, Cultured
CHO cells
Copolymers
Cricetinae
Cricetulus
Drug Synergism
Electron paramagnetic resonance
Glutathione - metabolism
Hypoxia
Maleates - administration & dosage
Melanin
Mice
Mice, Inbred BALB C
Misonidazole - administration & dosage
Neoplasms, Experimental - metabolism
Oxygen Consumption
Phytopathology
Radiation tolerance
Radiotherapy
Thiols
Tumors
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Summary:Depletion of glutathione in Chinese hamster ovary cells in vitro by diethyl maleate resulted in enhancement of the effect of x-rays on cell survival under hypoxic conditions but not under oxygenated conditions. Hypoxic EMT6 tumor cells were similarly sensitized in vivo. The action of diethyl maleate is synergistic with the effect of the electron-affinic radiosensitizer misonidazole, suggesting that the effectiveness of misonidazole in cancer radiotherapy may be improved by combining it with drugs that deplete intracellular glutathione.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7089580