Somatomedin C: Restoration in Vivo of Cycle Traverse in G 0 /G 1 Blocked Cells of Hypophysectomized Animals

DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is rest...

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Published in:Science (American Association for the Advancement of Science) 1980-04, Vol.208 (4442), p.410-412
Main Authors: Rothstein, Howard, Van Wyk, Judson J., Hayden, John H., Gordon, Sheldon R., Weinsieder, Allan
Format: Article
Language:English
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Summary:DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is restored by growth hormone and triiodothyronine.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7189293