cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and...

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Published in:Science (American Association for the Advancement of Science) 1994-08, Vol.265 (5176), p.1231-1234
Main Authors: Akiyama, Kin-ya, Yokota, Kim-ya, Kagawa, Susumu, Shimbara, Naoki, Tamura, Tomohiro, Akioka, Hiroshi, Nothwang, Hans G., Noda, Chiseko, Tanaka, Keiji, Ichihara, Akira
Format: Article
Language:English
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Summary:Proteasomes are the proteolytic complex responsible for major histocompatibility complex (MHC) class I-restricted antigen presentation. Interferon γ treatment increases expression of MHC-encoded LMP2 and LMP7 subunits of the proteasome and decreases expression of two proteasome subunits, named X and Y, which alters the proteolytic specificity of proteasomes. Molecular cloning of complementary DNAs encoding X and Y showed that their proteins are proteasomal subunits with high amino acid similarity to LMP7 and LMP2, respectively. Thus, interferon γ may induce subunit replacements of X and Y by LMP7 and LMP2, respectively, producing proteasomes perhaps more appropriate for the immunological processing of endogenous antigens.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8066462