Glyoxalase I Polymorphism in the Mouse: A New Genetic Marker Linked to H-2

Two electrophoretically distinct variants of glyoxalase I (Glo-1) are present in mouse (Mus musculus). The two forms are controlled by two codominant alleles Glo-1$^{a}$ (common) and Glo-1$^{b}$ (rare) at an autosomal locus. A linkage study showed that Glo-1 maps at approximately 3 centimorgans from...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-10, Vol.198 (4314), p.311-313
Main Authors: Meo, Tommaso, Douglas, Tommy, Rijnbeek, Ann-Marie
Format: Article
Language:English
Subjects:
Alleles
Alveolar macrophages
Animals
Biological Evolution
Chromosome Mapping
Cigarette smoking
Cultured cells
Enzymes
Erythrocytes - enzymology
Genes
Genetic Linkage
Genetic loci
H-2 Antigens - genetics
HLA antigens
Humans
Inbred strains
Lactoylglutathione Lyase - blood
Lactoylglutathione Lyase - genetics
Lyases - genetics
Mice
Mice, Inbred Strains
Polymorphism, Genetic
Recombination, Genetic
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Summary:Two electrophoretically distinct variants of glyoxalase I (Glo-1) are present in mouse (Mus musculus). The two forms are controlled by two codominant alleles Glo-1$^{a}$ (common) and Glo-1$^{b}$ (rare) at an autosomal locus. A linkage study showed that Glo-1 maps at approximately 3 centimorgans from the Ss locus of the H-2 histocompatibility region. A similar linkage relationship exists in man between GLO and HLA, the human homolog of the H-2 gene complex. Thus, the chromosomal segment evolutionarily preserved in the two species is longer than previously suspected, and it includes genes with no obvious functional relation to the other components of the major histocompatibility complex. Several features of the Glo-1 polymorphism in the mouse recommend it as a marker of choice for the H-2 region.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.910130