Selective Brain Dopamine Depletion in Developing Rats: An Experimental Model of Minimal Brain Dysfunction

Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected chil...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-01, Vol.191 (4224), p.305-308
Main Authors: Shaywitz, Bennett A., Yager, Robert D., Klopper, Jeffrey H.
Format: Article
Language:English
Subjects:
Age Factors
Amphetamine - pharmacology
Amphetamine - therapeutic use
Animals
Animals, Newborn
Attention Deficit Disorder with Hyperactivity - chemically induced
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - physiopathology
Avoidance Learning - physiology
Bottles
Brain - metabolism
Catecholamines
Children
Disease Models, Animal
Dopamine - deficiency
Humans
Hydroxydopamines
Hyperactivity
Meditation
Minimal brain disorders
Motor activity
Motor Activity - physiology
Norepinephrine
Norepinephrine - metabolism
Rats
Sleep
Sleep stages
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Summary:Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected children. This suggests a functional deficiency of brain dopamine in the pathogenesis of minimal brain dysfunction.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.942800