Science Signaling Podcast: 1 October 2013

A subset of 26 S proteasomes attenuates TLR3-mediated antiviral signaling. This Podcast features an interview with Carlos Gorbea, author of a Research Article that appears in the 1 October 2013 issue of Science Signaling on the role of proteasomes in TLR3 signaling. TLR3 is a member of the Toll-like...

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Bibliographic Details
Published in:Science signaling 2013-10, Vol.6 (295)
Main Authors: Gorbea, Carlos, VanHook, Annalisa M.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
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Summary:A subset of 26 S proteasomes attenuates TLR3-mediated antiviral signaling. This Podcast features an interview with Carlos Gorbea, author of a Research Article that appears in the 1 October 2013 issue of Science Signaling on the role of proteasomes in TLR3 signaling. TLR3 is a member of the Toll-like receptor family, which is a group of related receptors that detect the presence of pathogens and trigger innate immune responses. TLR3 is localized to endosomes and activated by binding to double-stranded RNA, which is the genetic material of some viruses. Gorbea and colleagues found that depletion of Ecm29, which is an adaptor protein associated with a subset of 26 S proteasomes, increased TLR3 signaling by inhibiting both the proteasomal degradation of TLR3 effectors and the autophagic degradation of TLR3 and TLR3 effectors.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.2004729