Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung

• Published in: Antimicrobial Agents and Chemotherapy 2007-10, Vol.51 (10), p.3771-3774
• Main Authors: DE JESUS VALLE, Maria José, GONZALEZ LOPEZ, Francisco, DOMINGUEZ-GIL HURLE, Alfonso, SANCHEZ NAVARRO, Amparo
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Biological and medical sciences; Body Fluids - drug effects; Body Fluids - metabolism; Bronchoalveolar Lavage Fluid - chemistry; Experimental Therapeutics; In Vitro Techniques; Lung; Lung - metabolism; Male; Medical sciences; Pharmacology. Drug treatments; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - metabolism; Rats; Rats, Wistar; Respiration, Artificial; Respiratory Mechanics - physiology; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00099-07

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