Bioengineered Lysozyme Reduces Bacterial Burden and Inflammation in a Murine Model of Mucoid Pseudomonas aeruginosa Lung Infection

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Published in:Antimicrobial Agents and Chemotherapy 2013-11, Vol.57 (11), p.5559-5564
Main Authors: TENEBACK, Charlotte C, SCANLON, Thomas C, WARGO, Matthew J, BEMENT, Jenna L, GRISWOLD, Karl E, LECLAIR, Laurie W
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria
Biological and medical sciences
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Colony Count, Microbial
Cytokines - biosynthesis
Cytokines - immunology
Experimental Therapeutics
Glycosaminoglycans - biosynthesis
Glycosaminoglycans - secretion
Humans
Inflammation - prevention & control
Lung
Lung - drug effects
Lung - microbiology
Male
Medical sciences
Mice
Mice, Inbred C57BL
Muramidase
Muramidase - chemistry
Muramidase - genetics
Muramidase - pharmacology
Pharmacology. Drug treatments
Protein Engineering
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - growth & development
Pseudomonas Infections
Pseudomonas Infections - drug therapy
Pseudomonas Infections - immunology
Pseudomonas Infections - microbiology
Static Electricity
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00500-13