Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying bla GES-5 from Guangzhou, China

Klebsiella pneumoniae strain KP01 carrying bla GES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned bla GES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids f...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2016-10, Vol.60 (10), p.6362-6364
Main Authors: Chen, Ding-Qiang, Wu, Ai-Wu, Yang, Ling, Su, Dan-Hong, Lin, Yong-ping, Hu, Yan-Wei, Zheng, Lei, Wang, Qian
Format: Article
Language:English
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Summary:Klebsiella pneumoniae strain KP01 carrying bla GES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned bla GES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array of orf28-orf28-bla GES-5 was identified on pGES-GZ, within which orf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00764-16