Mechanism of Entecavir Resistance of Hepatitis B Virus with Viral Breakthrough as Determined by Long-Term Clinical Assessment and Molecular Docking Simulation

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Published in:Antimicrobial Agents and Chemotherapy 2010-02, Vol.54 (2), p.882-889
Main Authors: MUKAIDE, Motokazu, TANAKA, Yasuhito, ORITO, Etsuro, INOUE, Manami, BAQAI, Sumbella, LAI, Ching-Lung, MIZOKAMI, Masashi, SHIN-I, Tadasu, YUEN, Man-Fung, KURBANOV, Fuat, YOKOSUKA, Osamu, SATA, Michio, KARINO, Yoshiyasu, YAMADA, Gotaro, SAKAGUCHI, Kohsaku
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological and medical sciences
Computer Simulation
Cross-Sectional Studies
DNA, Viral - genetics
Drug Resistance, Viral
Drug Resistance, Viral - genetics
Female
Guanine
Guanine - analogs & derivatives
Guanine - pharmacology
Guanine - therapeutic use
Hepatitis B - drug therapy
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - drug effects
Hepatitis B virus - genetics
Hepatitis B virus - physiology
Human viral diseases
Humans
Infectious diseases
Lamivudine - pharmacology
Lamivudine - therapeutic use
Male
Medical sciences
Middle Aged
Mutation
Pharmacology. Drug treatments
Polymerase Chain Reaction
RNA-Directed DNA Polymerase - genetics
Viral diseases
Viral hepatitis
Viral Proteins - genetics
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01061-09