Modeling combinations of antiretroviral agents in vitro with integration of pharmacokinetics: guidance in regimen choice for clinical trial evaluation

• Published in: Antimicrobial Agents and Chemotherapy 1996-05, Vol.40 (5), p.1143-1147
• Main Authors: DRUSANO, G. L, PRICHARD, M, BILELLO, P. A, BILELLO, J. A
• Format: Article
• Language: English
• Subjects: AIDS/HIV; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Antiviral Agents - administration & dosage; Antiviral Agents - pharmacokinetics; Biological and medical sciences; Cell Line; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections - drug therapy; HIV Protease Inhibitors - pharmacology; HIV-1 - drug effects; human immunodeficiency virus; Medical sciences; Methylurea Compounds; Methylurea Compounds - administration & dosage; Methylurea Compounds - pharmacokinetics; Models, Biological; Monte Carlo Method; Pharmacology. Drug treatments; Pyridines; Pyridines - administration & dosage; Pyridines - pharmacokinetics; Zidovudine; Zidovudine - administration & dosage; Zidovudine - pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.40.5.1143

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