Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora

Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus SALINISPORA: The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite produ...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 2007-02, Vol.73 (4), p.1146-1152
Main Authors: Jensen, Paul R, Williams, Philip G, Oh, Dong-Chan, Zeigler, Lisa, Fenical, William
Format: Article
Language:English
Subjects:
Aquatic life
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genotype & phenotype
Metabolism
Microbial Ecology
Microbiology
Micromonosporaceae - classification
Micromonosporaceae - genetics
Micromonosporaceae - metabolism
Molecular Sequence Data
RNA, Ribosomal, 16S - analysis
Seawater - microbiology
Species Specificity
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Summary:Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus SALINISPORA: The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite production can be a species-specific, phenotypic trait associated with broadly distributed bacterial populations. Associations between actinomycete phylotype and chemotype revealed an effective, diversity-based approach to natural product discovery that contradicts the conventional wisdom that secondary metabolite production is strain specific. The structural diversity of the metabolites observed, coupled with gene probing and phylogenetic analyses, implicates lateral gene transfer as a source of the biosynthetic genes responsible for compound production. These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.01891-06