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Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we de...
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| Published in: | Eukaryotic Cell 2011-09, Vol.10 (9), p.1264-1268 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c617t-105b2d5a52698cf9893208b87c4fae4e3cb0203d416f392206b05a46cb2310de3 |
| container_end_page | 1268 |
| container_issue | 9 |
| container_start_page | 1264 |
| container_title | Eukaryotic Cell |
| container_volume | 10 |
| creator | Baker, Lorina G Specht, Charles A Lodge, Jennifer K |
| description | Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host. |
| doi_str_mv | 10.1128/ec.05138-11 |
| format | article |
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| fulltext | fulltext |
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| ispartof | Eukaryotic Cell, 2011-09, Vol.10 (9), p.1264-1268 |
| issn | 1535-9778 1535-9786 |
| language | eng |
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| source | American Society for Microbiology Journals; PubMed Central |
| subjects | Animals Cell Wall Cell Wall - genetics Cell Wall - metabolism cell walls chitin Chitin - genetics Chitin - metabolism chitosan Chitosan - metabolism Cryptococcosis Cryptococcosis - microbiology Cryptococcosis - pathology Cryptococcus neoformans Cryptococcus neoformans - genetics Cryptococcus neoformans - growth & development Cryptococcus neoformans - pathogenicity Fungal Proteins Fungal Proteins - genetics Fungal Proteins - metabolism fungi Gene Expression Regulation, Fungal genetics glucans Glucans - genetics Glucans - metabolism growth & development mammals meningoencephalitis metabolism Mice microbiology Mutation pathogenicity pathogens pathology proteins virulence Virulence - genetics |
| title | Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans |
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