dbpBA Locus of Borrelia burgdorferi Is Not Essential for Infection of Mice

The Lyme disease spirochete Borrelia burgdorferi expresses a broad array of adhesive molecules, including the decorin-binding proteins A and B (DbpA and DbpB), which are believed to play important roles in mammalian infection. The dbpBA locus was deleted; resulting mutants were able to infect both i...

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Bibliographic Details
Published in:Infection and Immunity 2006-11, Vol.74 (11), p.6509-6512
Main Authors: Shi, Yanlin, Xu, Qilong, Seemanapalli, Sunita V, McShan, Kristy, Liang, Fang Ting
Format: Article
Language:English
Subjects:
Adhesins, Bacterial - genetics
Adhesins, Bacterial - physiology
Animals
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - physiology
Bacteriology
Biological and medical sciences
Borrelia burgdorferi
Borrelia burgdorferi - genetics
Borrelia burgdorferi - pathogenicity
Fundamental and applied biological sciences. Psychology
Genetic Markers
Lyme Disease - metabolism
Lyme Disease - microbiology
Mice
Mice, Inbred BALB C
Mice, SCID
Microbiology
Miscellaneous
Molecular Pathogenesis
Mutation
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Summary:The Lyme disease spirochete Borrelia burgdorferi expresses a broad array of adhesive molecules, including the decorin-binding proteins A and B (DbpA and DbpB), which are believed to play important roles in mammalian infection. The dbpBA locus was deleted; resulting mutants were able to infect both immunodeficient and immunocompetent mice, indicating that neither DbpA nor DbpB is essential for the infection of mammals, although the DbpAB deficiency may significantly attenuate infectivity potential.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.00740-06