New Functions for the Ancient DedA Membrane Protein Family

The DedA protein family is a highly conserved and ancient family of membrane proteins with representatives in most sequenced genomes, including those of bacteria, archaea, and eukarya. The functions of the DedA family proteins remain obscure. However, recent genetic approaches have revealed importan...

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Bibliographic Details
Published in:Journal of Bacteriology 2013, Vol.195 (1), p.3-11
Main Authors: Doerrler, William T, Sikdar, Rakesh, Kumar, Sujeet, Boughner, Lisa A
Format: Article
Language:English
Subjects:
Archaea
bacteria
Bacteria - genetics
Bacteria - metabolism
Bacterial proteins
Bacteriology
Borrelia burgdorferi
cell division
Escherichia coli
Gene Expression Regulation, Bacterial - physiology
genome
Genotype & phenotype
Homeostasis
lipid composition
membrane proteins
Membrane Proteins - genetics
Membrane Proteins - metabolism
Membrane Proteins - physiology
Membranes
Minireview
Multigene Family
mutants
Mutation
phenotype
Phylogenetics
Phylogeny
stress response
temperature
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Summary:The DedA protein family is a highly conserved and ancient family of membrane proteins with representatives in most sequenced genomes, including those of bacteria, archaea, and eukarya. The functions of the DedA family proteins remain obscure. However, recent genetic approaches have revealed important roles for certain bacterial DedA family members in membrane homeostasis. Bacterial DedA family mutants display such intriguing phenotypes as cell division defects, temperature sensitivity, altered membrane lipid composition, elevated envelope-related stress responses, and loss of proton motive force. The DedA family is also essential in at least two species of bacteria: Borrelia burgdorferi and Escherichia coli. Here, we describe the phylogenetic distribution of the family and summarize recent progress toward understanding the functions of the DedA membrane protein family.
ISSN:0021-9193
1098-5530
1067-8832
DOI:10.1128/JB.01006-12